Anxiolytic effect of aridanin isolated from Tetrapleura tetraptera in mice
作者： OA Aderibigbe , OE Iwalewa , KS Adesina , IO Agboola
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摘要: The study was carried out to investigate the anxiolytic properties of aridanin isolated from Tetrapleura tetraptera in mice. Elevated plus-maze used effect. possible involvement GABAA - benzodiazepine receptor complex also investigated using flumazenil. Aridanin at doses 5 and 10 mg/kg, i.p. administered 30 min prior induced effect expressed by increase number entries time spent open arms percentage arm decrease closed arms. treatment mice with flumazenil (2.0 i.p.) 15 before administration (10 blocked It found that an which may be mediated through interaction GABAAbenzodiazepine
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