Involvement of GABAA-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensis

摘要: Abstract To investigate the ability of hexanic ethanolic fraction Rubus brasiliensis Martius (Roseceae), to induce anxiolytic effect and also possible involvement GABA A -benzodiazepine receptor complex, male Wistar rats Swiss mice behaviour were tested in elevated plus maze (EPM). All doses extract, 50, 100 150 mg/kg, administered per gavage (vo), 30 min before behavioural evaluation, induced an expressed by: increased number entries time spent open arms percentage arm entries; decreased closed arms. The treatment with flumazenil (Ro 15-1788), 0.5, 1.0 1.5 i.p., 15-min administration fraction, vo, blocked fraction-induced effect. LD 50 for was 1512 mg/kg. In conclusion, it shown that R. mice. This can be attributed a liposoluble principle low toxicity which may acting as agonist on complex.