In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo.

摘要: Abstract Ethnopharmacological relevance The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for treatment various parasitic diseases collected after an ethnopharmacological inventory conducted in Bolongo area, Bandundu province DR Congo, was evaluated. Materials methods Decoctions were prepared, lyophilized evaluated vitro against Trypanosoma b. brucei , cruzi Leishmania infantum chloroquine- pyrimethamine-resistant K1 strain Plasmodium falciparum . Cytotoxicity MRC-5 cells included to assess selectivity activity. Results Most tested exhibited pronounced (IC 50  ≤ 5 μg/ml) or good (5   ≤ 10 μg/ml) one more selected protozoa. A total 19 plant inhibited especially extract Isolona hexaloba stem bark  = 1.95 μg/ml, SI = 16.5); 8 active Enanatia chlorantha Quassia africana root being most with IC values 1.87 1.88 μg/ml, respectively (SI = 3.0 3.3, respectively); showed Napoleona vogelii as 5.66 5.04 μg/ml (SI = 11.3 1.2). Finally, 9 (root bark) ones 0.46 1.27 μg/ml (SI = 13.7 13.6). Extracts Enantia bark, Piptadeniastrum africanum (CC Conclusions These results can partly support justify use some these species diseases.