High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature.
作者： Carola W. N. Damen , Hilde Rosing , Jan H. M. Schellens , Jos H. Beijnen
DOI: 10.1002/BMC.1271
关键词:
摘要: The bioanalysis of vinca-alkaloids has been investigated extensively. High-performance liquid chromatography coupled to ultraviolet, fluorescence or electrochemical detection have described. During recent years chromato-graphy with mass spectrometry (LC-MS) become the first choice for quantitative vinca anticancer agents. This paper reviews methods bio-analysis using LC-MS, supplemented our own experience. We will focus on sample pre-treatment, and MS pay attention problems which can occur during vinca-alkaloids. These encounter carry-over absorption effects solutions be provided how circumvent these problems. Copyright © 2009 John Wiley & Sons, Ltd.
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