Brain edema in neurooncology: Radiological assessment and management

摘要: Vasogenic brain edema is a common diagnostic and management problem in tumor patients. Molecular mechanisms play role the pathophysiology, including abnormalities of endothelium, vascular endothelial growth factor leukotriene synthase. Edema diagnosis facilitated by development neuroradiological imaging techniques, with diffusion-weighted (DW-MRI) differentiating grades or abscesses tumors, diffusion tensor representing an advanced technique to potentially differentiate malignant glioma from metastasis facilitate preoperative planning. prognostic for meningioma metastases but not glioma. Therapy includes, amongst others, tumor-directed measures such as debulking surgery, radio- chemotherapy. However, local therapeutic approaches might also induce exacerbate formation. Peritumoral can usually be managed corticosteroids. patients on corticosteroids are at greater risk metabolic changes, Pneumocystis carinii pneumonia, thromboembolism. More recently, inhibitors cyclooxygenase-2 well boswellic acids have been explored antiedema agents tumors.