Down-regulation of the progesterone receptor by the methylation of progesterone receptor gene in endometrial cancer cells.
作者： Yun Ren , Xishi Liu , Duan Ma , Youji Feng , Nanbert Zhong
DOI: 10.1016/J.CANCERGENCYTO.2007.02.002
关键词:
摘要: Progesterone plays an important role in the regulation of normal endometrium function by binding to progesterone receptor (PR). In endometrial cancer, however, PR is always down-regulated. Previous reports showed that methylation promoter region gene may be responsible for PRB isoform repression. However, CpG islands exon are much richer and longer than region. We hypothesize also take part down-regulation gene. The status first cell cultures was investigated. Aberrant patterns were observed gene, density correlated with differentiation different types cancer cells. DNA methyltransferase (DNMT) histone deacetylase inhibitor 5-aza-2'-deoxycytidine (ADC), as well trichostatin A (TSA), which reverses expression, studied. combination ADC TSA resulted synergistic effects inducing DNMT1 DNMT3A, could have antigrowth effect on cells apoptosis.
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