DNA methylation in endometrial cancer.
作者： Meng Hua Tao , Jo L. Freudenheim
关键词: Gene 、 Cancer research 、 Gene expression 、 Endometrial cancer 、 Carcinoma 、 Epigenetics 、 Biology 、 DNA methylation 、 Cancer 、 Cancer epigenetics
摘要: Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic, epigenetic alterations, as well environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic modifiable features of many types. A significant change DNA methylation. In this review, we review evidence on role methylation, examining relation endometrial carcinogenesis, report recent advances understanding contribution methylation with emphasis dietary/ lifestyle factors, opportunities challenges management prevention.
sci-hub.se 参考文章(148)
P Bufo, A Di Spiezio Sardo, G Pannone, F Sanguedolce, M Guida, G Bifulco, C Nappi, Aberrant DNA hypermethylation of hMLH-1 and CDKN2A/p16 genes in benign, premalignant and malignant endometrial lesions. European Journal of Gynaecological Oncology. ,vol. 30, pp. 267- 270 ,(2009)
Hui-Juan Yang, Vincent WS Liu, Yue Wang, Percy CK Tsang, Hextan YS Ngan, Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. BMC Cancer. ,vol. 6, pp. 212- 212 ,(2006) , 10.1186/1471-2407-6-212
Marian S. Blazes, Kathleen R. Cho, Brigitte M. Ronnett, Lora Hedrick, Bastiaan van Rees, Anouk R. Lambers, Hidetaka Katabuchi, Fred S. Leach, Mutations in DNA Mismatch Repair Genes Are Not Responsible for Microsatellite Instability in Most Sporadic Endometrial Carcinomas Cancer Research. ,vol. 55, pp. 5556- 5560 ,(1995)
Marian S. Blazes, Kathleen R. Cho, Steven I. Wang, Ramon Parsons, Shikha Bose, Lora Hedrick Ellenson, Hironori Tashiro, Jing Li, Rong Wu, Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Research. ,vol. 57, pp. 3935- 3940 ,(1997)
Kim S. Kraunz, Debra Hsiung, Michael D. McClean, Mei Liu, Joyce Osanyingbemi, Heather H. Nelson, Karl T. Kelsey, Dietary folate is associated with p16INK4A methylation in head and neck squamous cell carcinoma International Journal of Cancer. ,vol. 119, pp. 1553- 1557 ,(2006) , 10.1002/IJC.22013
Bharati Bapat, Michele Zysman, Anna Millar, Julia Knight, William Chapman, Asantha Saka, Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype. Cancer Research. ,vol. 62, pp. 3663- 3666 ,(2002)
Elizabeth Litman, Gareth Owen, Nirmala S. Kumar, Kimberly K. Leslie, Jennifer Richer, Kathryn B. Horwitz, Selective Down-Regulation of Progesterone Receptor Isoform B in Poorly Differentiated Human Endometrial Cancer Cells: Implications for Unopposed Estrogen Action Cancer Research. ,vol. 58, pp. 1860- 1865 ,(1998)
Gen Tamura, A. Steven Fleisher, Stephen J. Meltzer, Manel Esteller, Tong Tong Zou, Stephen P. James, Jing Yin, Keith T. Wilson, Suna Wang, James G. Herman, Steven M. Powell, Mun Gan Rhyu, John M. Abraham, Dehe Kong, Kara N. Smolinski, Ying Qiang Shi, Hiroyuki Suzuki, Hypermethylation of the hMLH1 Gene Promoter in Human Gastric Cancers with Microsatellite Instability Cancer Research. ,vol. 59, pp. 1090- 1095 ,(1999)
Abhipsa Dharia, Rajvir Dahiya, Masahiro Sasaki, Yuichiro Tanaka, Bong R. Oh, Sei-ichiro Fujimoto, Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer. Cancer Research. ,vol. 61, pp. 97- 102 ,(2001)
Wolf Reik, Wendy Dean, Jorn Walter, Epigenetic Reprogramming in Mammalian Development Science. ,vol. 293, pp. 1089- 1093 ,(2001) , 10.1126/SCIENCE.1063443