Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data.
作者： Hui-Juan Yang , Vincent WS Liu , Yue Wang , Percy CK Tsang , Hextan YS Ngan
关键词:
摘要: Background Epigenetic gene silencing is one of the major causes carcinogenesis. Its widespread occurrence in cancer genome could inactivate many cellular pathways including DNA repair, cell cycle control, apoptosis, adherence, and detoxification. The abnormal promoter methylation might be a potential molecular marker for management.
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