Signalling shortcuts: cell-surface receptors in the nucleus?

作者: Alan Wells , Ulrich Marti

DOI: 10.1038/NRM905

关键词:

摘要: Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there what function serve this location? Recent advances have provided tantalizing hints to answers these questions, hold key identifying a new mode of signal transduction.

参考文章(27)
Alan Wells, The EGF Receptor Signaling System Springer, Boston, MA. pp. 57- 79 ,(2002) , 10.1007/978-1-4757-3600-7_4
N Longo, R.C. Shuster, L.D. Griffin, S.D. Langley, L.J. Elsas, Activation of insulin receptor signaling by a single amino acid substitution in the transmembrane domain. Journal of Biological Chemistry. ,vol. 267, pp. 12416- 12419 ,(1992) , 10.1016/S0021-9258(18)42290-9
Michael David, Lily Wong, Richard Flavell, Stewart A. Thompson, Alan Wells, Andrew C. Larner, Gibbes R. Johnson, STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin REQUIREMENT FOR THE EGF RECEPTOR KINASE BUT NOT FOR TYROSINE PHOSPHORYLATION SITES OR JAK1 Journal of Biological Chemistry. ,vol. 271, pp. 9185- 9188 ,(1996) , 10.1074/JBC.271.16.9185
Steven E. Raper, Susan Jo Burvven, Mary E. Barker, Albert L. Jones, Translocation of Epidermal Growth Factor to the Hepatocyte Nucleus During Rat Liver Regeneration Gastroenterology. ,vol. 92, pp. 1243- 1250 ,(1987) , 10.1016/S0016-5085(87)91084-5
B. Mroczkowski, G. Mosig, S. Cohen, ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA Nature. ,vol. 309, pp. 270- 273 ,(1984) , 10.1038/309270A0
C.-H. Heldin, SIGNAL TRANSDUCTION: RIPping Tyrosine Kinase Receptors Apart Science. ,vol. 294, pp. 2111- 2113 ,(2001) , 10.1126/SCIENCE.1067628
M. Katoh, Y. Hattori, H. Sasaki, M. Tanaka, K. Sugano, Y. Yazaki, T. Sugimura, M. Terada, K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 2960- 2964 ,(1992) , 10.1073/PNAS.89.7.2960
Mark A. Lemmon, Joseph Schlessinger, Cell signaling by receptor-tyrosine kinases Cell. ,vol. 141, pp. 1117- 1134 ,(2000) , 10.1016/J.CELL.2010.06.011