Targeting HER (ERBB) signaling in head and neck cancer: An essential update.
作者： Jun Zhang , Nabil F Saba , Georgia Zhuo Chen , Dong M Shin , None
DOI: 10.1016/J.MAM.2015.07.001
关键词:
摘要: Abstract HNC (head and neck cancer) remains the 6th most common carcinoma worldwide. The suboptimal survival toxicities observed with conventional approaches warrant exploration of novel therapeutic strategies such as targeted therapies. Although targeting EGFR (epidermal growth factor receptor) cetuximab demonstrated clinical promise, HER (human epidermal or ERBB (erythroblastic leukemia viral oncogene homolog) therapy in has overall been to date settings. Overcoming resistance well identifying new therefore a significant challenge. In this review, we will discuss emerging roles members besides EGFR. A comprehensive “three-dimensional” view signaling pathway from importance nuclear translocation our maturing concept receptors' “spatial regulation”, interdependence interaction among different also be addressed complete an essential update HNC.
elsevier.com
sci-hub.se 参考文章(113)
Alexander Hoellein, Anja Pickhard, Fabienne von Keitz, Stephanie Schoeffmann, Guido Piontek, Martina Rudelius, Anja Baumgart, Stefan Wagenpfeil, Christian Peschel, Tobias Dechow, Henning Bier, Ulrich Keller, Aurora kinase inhibition overcomes cetuximab resistance in squamous cell cancer of the head and neck. Oncotarget. ,vol. 2, pp. 599- 609 ,(2011) , 10.18632/ONCOTARGET.311
Alan Wells, Ulrich Marti, Signalling shortcuts: cell-surface receptors in the nucleus? Nature Reviews Molecular Cell Biology. ,vol. 3, pp. 697- 702 ,(2002) , 10.1038/NRM905
Steven Seelig, Carlos L. Arteaga, Walter King, F. Michael Yakes, Wichai Chinratanalab, Christoph A. Ritter, Herceptin-induced Inhibition of Phosphatidylinositol-3 Kinase and Akt Is Required for Antibody-mediated Effects on p27, Cyclin D1, and Antitumor Action Cancer Research. ,vol. 62, pp. 4132- 4141 ,(2002)
David Ira Rosenthal, Paul M. Harari, Jordi Giralt, Diana Bell, David Raben, Joyce Liu, Jeltje Schulten, K. Kian Ang, James A. Bonner, Impact of p16 status on the results of the phase III cetuximab (cet)/radiotherapy (RT). Journal of Clinical Oncology. ,vol. 32, pp. 6001- 6001 ,(2014) , 10.1200/JCO.2014.32.15_SUPPL.6001
Klaus Dittmann, Claus Mayer, Hans-Peter Rodemann, Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity Radiotherapy and Oncology. ,vol. 76, pp. 157- 161 ,(2005) , 10.1016/J.RADONC.2005.06.022
Yosef Yarden, Mark X. Sliwkowski, Untangling the ErbB signalling network Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 127- 137 ,(2001) , 10.1038/35052073
Alexander Sorkin, Mark von Zastrow, Endocytosis and signalling: intertwining molecular networks Nature Reviews Molecular Cell Biology. ,vol. 10, pp. 609- 622 ,(2009) , 10.1038/NRM2748
Ran Brosh, Varda Rotter, When mutants gain new powers: news from the mutant p53 field Nature Reviews Cancer. ,vol. 9, pp. 701- 713 ,(2009) , 10.1038/NRC2693
Klaus Dittmann, Claus Mayer, Birgit Fehrenbacher, Martin Schaller, Uma Raju, Luka Milas, David J. Chen, Rainer Kehlbach, H. Peter Rodemann, Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase Journal of Biological Chemistry. ,vol. 280, pp. 31182- 31189 ,(2005) , 10.1074/JBC.M506591200
Chunrong Li, Mari Iida, Emily F. Dunn, Deric L. Wheeler, Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma Radiotherapy and Oncology. ,vol. 97, pp. 330- 337 ,(2010) , 10.1016/J.RADONC.2010.06.010