Use of catheter-tip velocity--pressure transducer to evaluate left ventricular function in man: effects of intravenous propranolol.

摘要: A catheter-tip velocity transducer with two high-fidelity pressure manometers was used to evaluate the left ventricular (LV) hemodynamic effects of intravenous propranolol (10 mg). Nine patients without clinical evidence heart failure were studied. Pulsatile ascending aortic blood flow and LV measured continuously during drug administration. Beat-to-beat changes in stroke volume index, work end-diastolic pressure, maximum acceleration, dP/dt determined. Propranolol produced a decrease (from 58 +/- 4.7 42 5.1 cm/sec, p less than 0.002), acceleration 1181 130 847 117 cm/sec2, 0.002, max 1361 70 1146 63 mm Hg/sec, index 47 3.0 38 3.2 ml/m2, 0.002) total 702 33 603 44 mJ/m2 0.04), little change mean peak systolic pressure. Depression myocardial function detectable within 1 minute after initiation persisted when negative chronotropic eliminated by atrial pacing. The multisensor catheter technique allows rapid safe detection cardiovascular administration conscious man.