Fluoroalkyl‐Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines
作者： Lucas Mertens , Katharina J. Hock , Rene M. Koenigs
关键词:
摘要: A novel continuous-flow approach for the synthesis of fluoroalkyl-substituted diazomethanes has been developed. Utilizing a cheap, self-made microreactor amines were transformed into corresponding using tert-butyl nitrite and acetic acid as catalyst. These employed in [2+3] cycloaddition reactions with olefins alkynes, yielding valuable pyrazolines pyrazoles good to excellent yields.
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