Adipose-derived Stem Cells Stimulated with n-Butylidenephthalide Exhibit Therapeutic Effects in a Mouse Model of Parkinson's Disease.

摘要: Parkinson's disease (PD) causes motor dysfunction and dopaminergic cell death. Drug treatments can effectively reduce symptoms but often cause unwanted side effects. Stem therapies using replacement or indirect beneficial secretomes have recently emerged as potential therapeutic strategies. Although various types of stem cells been proposed possible candidates, adipose-derived (ADSCs) are easily obtainable, more abundant, less ethically disputed, able to differentiate into multiple lineages. However, treatment PD adult is known be efficacious than neuron embryonic transplantation. Therefore, improved urgently needed. n-Butylidenephthalide (BP), which extracted from Angelica sinensis, has shown anti-inflammatory neuroprotective Indeed, we previously demonstrated that BP ADSCs enhances the expression neurogenesis homing factors such nuclear receptor related 1 protein, stromal-derived factor 1, brain-derived neurotrophic factor. In present study, examined ability BP-pretreated ADSC transplantation improve protect dopamine neurons in a mouse model PD. We evaluated results neuronal behavior tests beam walking, rotarod, locomotor activity tests. with without pretreatment were transplanted striatum. Our findings abilities varied efficacies stimulation effects Dopaminergic numbers returned normal ADSC-transplanted mice after 22 d. summary, stimulating recovery efficiency. Thus, our provide important new strategies for neurodegenerative diseases future studies.