Human adipose-derived stem cells stimulate neuroregeneration

摘要: Traumatic brain injuries and degenerative neurological disorders such as Alzheimer's dementia, Parkinson's disease, amyotrophic lateral sclerosis many others are characterized by loss of cells supporting structures. Restoring microanatomy function using stem is a promising therapeutic approach. Among the various sources, adipose-derived (ADSCs) one most easily harvested alternatives, they multiply rapidly, demonstrate low immunogenicity with an ability to differentiate into several cell types. The objective this study was evaluate effect xenotransplanted human ADSCs on post-traumatic regeneration rat sciatic nerve. Peripheral reconstruction following complete transection autonerve grafting complemented intra-operative injection hADSCs proximal distal stumps. injury caused gliosis apoptosis sensory neurons in lumbar 5 (L5) ganglia control rodents; however, animals treated demonstrated smaller amount cellular loss. Formation amputation neuroma, which hinders axonal repair, less prominent experimental group, immunohistochemical analysis myelin basic protein showed good myelination 65 days after surgery. At point, groups still exhibited high levels microglia/macrophage-specific marker Iba-1 proliferating nuclear antigen, mark ongoing inflammation incomplete growth 2 months injury. This report demonstrates that promote neuronal survival spinal ganglion, fuel repair stimulate peripheral nerves.