Origin and differentiation of microglia.

摘要: Microglia are the resident macrophage population of central nervous system (CNS). Adequate microglial function is crucial for a healthy CNS. not only first immune sentinels infection, contributing to both innate and adaptive responses locally, but also involved in maintenance brain homeostasis. Emerging data showing new fundamental roles microglia control neuronal proliferation differentiation, as well formation synaptic connections. While have been studied decades, long history experimental misinterpretation meant that their true origins remained debated. However, recent studies on origin indicate these cells fact arise early during development from progenitors embryonic yolk sac (YS) seed rudiment and, remarkably, appear persist there into adulthood. Here, we review discuss latest advances our understanding origin, homeostasis, which provides insights health disease.