Alcoholism and Rapid Progression to AIDS After Seroconversion

摘要: Rapid progression of infection with human immunodeficiency virus type 1 (HIV-1) to AIDS after seroconversion is rare; it has been associated coinfection by cytomegalovirus or T lymphotrophic I. We describe an alcoholic patient whose condition progressed 3 months HIV-1 occurred. Culture peripheral blood mononuclear cells yielded a syncytium-inducing variant HIV-1. lymphocytes showed no spontaneous cytotoxic activity against HIV-infected cells, nor could such be demonstrated following stimulation antigen in the presence recombinant interleukin-2. hypothesize that our patient's accelerated course was due alcohol abuse, which may have suppressed cell function and stimulated HIV replication.