The Cardioprotection of Silymarin in Coronary Artery Bypass Grafting Surgery

摘要: Coronary artery bypass grafting surgery (CABG) is one of the most effective therapies for coronary disease (CAD). CABG conventionally performed with use cardiopul‐ monary (CPB), which has been associated an increased frequency complications [1-3]. A variety risk factors described to help delineate assessment patients undergoing CABG, including preoperative left ventricular ejection fraction (LVEF) [4, 5] and postoperative increase in creatine kinase myocardial band (CK-MB) levels [6-11]. In (CABG), cardiopulmonary (CPB) combination aortic clamping during elicits ischemic injury [12]. The vascular endothelium a complex synthetic organ subject from numerous potential insults, oxidative stress [13, 14] modified lipoproteins [15], hemodynamic forces [16]. Injured endothelial cells initiate largely stereotyped, initially protective response. concurrent uptake low-density (LDLs) by monocyte-derived macrophages transforms them lipid laden foam that constitute key element fatty streak, first recognizable progenitor advanced atherosclerotic lesion [17, 18].