Brain Tumor Exosomes and Microvesicles: Pleiotropic Effects from Tiny Cellular Surrogates

作者: Michael W

DOI: 10.5772/21478

关键词:

摘要: Extracellular signaling is a necessity for tissue and organ system development, maintenance, adaptation survival. From the biologic unit of cell to complete organizational structure that organism, cell-cell, cell-tissue, tissue-organ, organ-system communication are essential keep organism functioning, homeostatic, proliferative. Cell-derived extracellular vesicles such as exosomes microvesicles vital players in these forms proximal distal messaging, acting discrete packets information capable altering recipient phenotypes, activities, responses. These part normal repertoire but particularly exploited by neoplasmic growths cancers change both local systemic environments aid tumor proliferation, invasion, metastases, defense tumor. This chapter will focus on from brain tumors, similar stories may be told about almost any type. Following this general introduction we discuss experimentally determined putative roles biology, stress responses, metabolism, migration, immunology, protection against chemotherapeutics.

参考文章(213)
M Iero, R Valenti, V Huber, P Filipazzi, G Parmiani, S Fais, L Rivoltini, Tumour-released exosomes and their implications in cancer immunity Cell Death & Differentiation. ,vol. 15, pp. 80- 88 ,(2008) , 10.1038/SJ.CDD.4402237
Francisca M. Santandreu, Marta Brell, Alexandra H. Gene, Rocío Guevara, Jordi Oliver, Marta E. Couce, Pilar Roca, Differences in mitochondrial function and antioxidant systems between regions of human glioma. Cellular Physiology and Biochemistry. ,vol. 22, pp. 757- 768 ,(2008) , 10.1159/000185559
Richard J Simpson, Justin WE Lim, Robert L Moritz, Suresh Mathivanan, Exosomes: proteomic insights and diagnostic potential Expert Review of Proteomics. ,vol. 6, pp. 267- 283 ,(2009) , 10.1586/EPR.09.17
Richard J. Simpson, Søren S. Jensen, Justin W. E. Lim, Proteomic profiling of exosomes: Current perspectives Proteomics. ,vol. 8, pp. 4083- 4099 ,(2008) , 10.1002/PMIC.200800109
Leonardo M.R. Ferreira, Cancer metabolism: the Warburg effect today. Experimental and Molecular Pathology. ,vol. 89, pp. 372- 380 ,(2010) , 10.1016/J.YEXMP.2010.08.006
Jessica McCready, Jessica D Sims, Doug Chan, Daniel G Jay, Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation BMC Cancer. ,vol. 10, pp. 294- 294 ,(2010) , 10.1186/1471-2407-10-294
Suresh Mathivanan, Hong Ji, Richard J. Simpson, Exosomes: extracellular organelles important in intercellular communication. Journal of Proteomics. ,vol. 73, pp. 1907- 1920 ,(2010) , 10.1016/J.JPROT.2010.06.006
Matias Ostrowski, Nuno B Carmo, Sophie Krumeich, Isabelle Fanget, Graça Raposo, Ariel Savina, Catarina F Moita, Kristine Schauer, Alistair N Hume, Rui P Freitas, Bruno Goud, Philippe Benaroch, Nir Hacohen, Mitsunori Fukuda, Claire Desnos, Miguel C Seabra, François Darchen, Sebastian Amigorena, Luis F Moita, Clotilde Thery, None, Rab27a and Rab27b control different steps of the exosome secretion pathway Nature Cell Biology. ,vol. 12, pp. 19- 30 ,(2010) , 10.1038/NCB2000
Igor Vivanco, Ingo K Mellinghoff, Epidermal growth factor receptor inhibitors in oncology Current Opinion in Oncology. ,vol. 22, pp. 573- 578 ,(2010) , 10.1097/CCO.0B013E32833EDBDF
M. Guescini, D. Guidolin, L. Vallorani, L. Casadei, A.M. Gioacchini, P. Tibollo, M. Battistelli, E. Falcieri, L. Battistin, L.F. Agnati, V. Stocchi, C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction Experimental Cell Research. ,vol. 316, pp. 1977- 1984 ,(2010) , 10.1016/J.YEXCR.2010.04.006