作者: Michael W
DOI: 10.5772/21478
关键词:
摘要: Extracellular signaling is a necessity for tissue and organ system development, maintenance, adaptation survival. From the biologic unit of cell to complete organizational structure that organism, cell-cell, cell-tissue, tissue-organ, organ-system communication are essential keep organism functioning, homeostatic, proliferative. Cell-derived extracellular vesicles such as exosomes microvesicles vital players in these forms proximal distal messaging, acting discrete packets information capable altering recipient phenotypes, activities, responses. These part normal repertoire but particularly exploited by neoplasmic growths cancers change both local systemic environments aid tumor proliferation, invasion, metastases, defense tumor. This chapter will focus on from brain tumors, similar stories may be told about almost any type. Following this general introduction we discuss experimentally determined putative roles biology, stress responses, metabolism, migration, immunology, protection against chemotherapeutics.