Consistent N-myc copy number in simultaneous or consecutive neuroblastoma samples from sixty individual patients.

摘要: Amplification of the N- myc oncogene is detected in about 30% untreated neuroblastomas. associated with advanced stages disease and rapid tumor progression. However, it was not known if copy number homogeneous tissue an individual patient, or changed time vivo . Therefore, we have made 66 observations on multiple simultaneous consecutive samples from 60 patients neuroblastoma. ( a ) Simultaneous were obtained different areas 31 masses 30 patients: similar (1–2, 3–10, >10) found all each patient. b anatomical sites ten patients. No difference seen. c Finally, 25 had two more over time. Thirteen single samples, 12 consistent levels amplification samples. Two latter cases second-look surgery sample, but no evident histologically. This study demonstrates that human neuroblastomas usually within tumor, only at sites, also times Overall, these findings suggest intrinsic biological property subset neuroblastomas, going to occur, generally present diagnosis.