EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

作者: Patrick J. Chitwood , Szymon Juszkiewicz , Alina Guna , Sichen Shao , Ramanujan S. Hegde

DOI: 10.1016/J.CELL.2018.10.009

关键词:

摘要: … with purified mammalian EMC in liposomes, suggesting that EMC can directly facilitate TMD … impacted by EMC disruption, we chose to analyze GPCRs. Earlier analysis had placed EMC’…

参考文章(55)
Ajay Sharma, Malaiyalam Mariappan, Suhila Appathurai, Ramanujan S. Hegde, In vitro dissection of protein translocation into the mammalian endoplasmic reticulum. Methods of Molecular Biology. ,vol. 619, pp. 339- 363 ,(2010) , 10.1007/978-1-60327-412-8_20
James C. Samuelson, Minyong Chen, Fenglei Jiang, Ines Möller, Martin Wiedmann, Andreas Kuhn, Gregory J. Phillips, Ross E. Dalbey, YidC mediates membrane protein insertion in bacteria. Nature. ,vol. 406, pp. 637- 641 ,(2000) , 10.1038/35020586
Peter Walter, Günter Blobel, Preparation of microsomal membranes for cotranslational protein translocation Methods in Enzymology. ,vol. 96, pp. 84- 93 ,(1983) , 10.1016/S0076-6879(83)96010-X
J P Beltzer, K Fiedler, I Geffen, M Spiess, H P Wessels, C Fuhrer, C Handschin, Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence. Journal of Biological Chemistry. ,vol. 266, pp. 973- 978 ,(1991) , 10.1016/S0021-9258(17)35269-9
Raymond J Louie, Jingyu Guo, John W Rodgers, Rick White, Najaf A Shah, Silvere Pagant, Peter Kim, Michael Livstone, Kara Dolinski, Brett A McKinney, Jeong Hong, Eric J Sorscher, Jennifer Bryan, Elizabeth A Miller, John L Hartman, A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis Genome Medicine. ,vol. 4, pp. 103- 103 ,(2012) , 10.1186/GM404
Florian Cymer, Gunnar von Heijne, Stephen H. White, Mechanisms of Integral Membrane Protein Insertion and Folding Journal of Molecular Biology. ,vol. 427, pp. 999- 1022 ,(2015) , 10.1016/J.JMB.2014.09.014