Heat shock protein 27 phosphorylation state is associated with cancer progression

摘要: Understanding the mechanisms that control stress-induced survival is critical to explain how tumors frequently resist treatment and improve current anti-cancer therapies. Cancer cells are able cope with stress escape drug toxicity by regulating heat shock proteins (Hsps) expression function. Hsp27 (HSPB1), a member of small Hsp family, represents one key players many signaling pathways contributing tumorigenicity, resistance, apoptosis inhibition. overexpressed in types cancer its functions regulated post-translational modifications, such as phosphorylation. Protein phosphorylation most widespread mechanism eukaryotic cells, it involved all fundamental cellular processes. Aberrant has been associated but molecular which implicated development progression remain undefined. This mini-review focuses on role potential usefulness therapeutic target cancer.