Exploring anti-TGF-β therapies in cancer and fibrosis

摘要: Transforming growth factor-β (TGF-β) is a multifunctional cytokine, with important roles in maintaining tissue homeostasis. TGF-β signals via transmembrane serine/threonine kinase receptors and intracellular Smad transcriptional regulators. Perturbed signaling has been implicated large variety of pathological conditions. Increased levels have found patients cancer, fibrosis, systemic sclerosis, were correlated disease severity. In mediates tumor invasion metastasis by affecting both cells the microenvironment including fibroblast activation immune suppression. Furthermore, strong stimulator extracellular matrix deposition.On basis these observations, small molecule inhibitors receptor kinases, neutralizing antibodies that interfere ligand–receptor interactions, antisense oligonucleotides reducing expression, soluble ectodomains sequester developed ...