TGF-β signaling regulates fibrotic expression and activity in carpal tunnel syndrome
作者： Anne Gingery , Tai-Hua Yang , Sandra M. Passe , Kai-Nan An , Chunfeng Zhao
DOI: 10.1002/JOR.22694
关键词:
摘要: Fibrosis of the subsynovial connective tissue (SSCT) is a predominant feature carpal tunnel syndrome (CTS). While nature CTS has been extensively studied, little known about etiology this disease. We investigated SSCT from patients with and control subjects using fibrosis arrays cell culture analysis. Twofold changes in fibrotic gene expression were found multiple genes patient arrays. This data was confirmed via qRT-PCR on subset genes; collagen I (Col1), III (Col3), growth factor (CTGF), transforming β (TGF-β), SMAD3 (P < 0.05) which significantly corroborate fold To further explore fibrosis, cells isolated tissue. Col1, Col3, TGF-β, highly expressed fibroblasts as compared to (P < 0.05). Further, decreased by inhibiting TGF-β receptor (TβRI) activity second messenger SMAD activated activation abrogated TβRI signaling These findings suggest that blocking may be an important therapeutic approach treating underlying patients. © 2014 Orthopaedic Research Society. Published Wiley Periodicals, Inc. J Orthop Res 32:1444–1450, 2014.
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