Anaerobic Growth of Candida albicans Does Not Support Biofilm Formation Under Similar Conditions Used for Aerobic Biofilm

作者: Swarajit K. Biswas , W. LaJean Chaffin

DOI: 10.1007/S00284-005-4552-3

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摘要: C. albicans is an opportunistic fungus causing life-threatening systemic infections particularly in immunocompromised individuals. The organism a commensal humans and grows either aerobically, e.g., the oral cavity, or anaerobically, gut. We studied anaerobic growth of defined yeast nitrogen base dextrose medium after adaptation subculturing chamber. At 37°C suspension culture, much slower was observed anaerobically with generation time 248 min compared to 98 for aerobic growth. Although grew well on solid medium, shaking increased rate culture at 37°C. Growth enhanced acidic pH neutral alkaline pH. Cells grown produced hyphae, but did not produce biofilm plastic surface denture acrylic under static conditions mild shaking, that support formation.

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