Animal models of intellectual disability: towards a translational approach.

摘要: Intellectual disability is a prevalent form of cognitive impairment, affecting 2-3% the general population. It daunting societal problem characterized by significant limitations both in intellectual functioning and adaptive behavior as expressed conceptual, social practical skills. clinically important disorder for which etiology pathogenesis are still poorly understood. Moreover, although tremendous progress has been made, pharmacological intervention currently non-existent therapeutic strategies remain limited. Studies humans have very limited capacity to explain basic mechanisms this condition. In sense, animal models invaluable investigation. Certainly, great deal knowledge that improved our understanding several pathologies derived from appropriate models. improve human health, scientific discoveries must be translated into applications. Translational research specifically aims at taking best practices benefit lives people communities. context, challenge science needs meet make use comparative approach most what each model can tell us. results many different genetic environmental insults. Taken together, present review will describe potential risk factors.