Modelling Proteasome and Proteasome Regulator Activities

摘要: Proteasomes are key proteases involved in a variety of processes ranging from the clearance damaged proteins to presentation antigens CD8+ T-lymphocytes. Which cleavage sites used within target and how fast these degraded have profound impact on immune system function many cellular metabolic processes. The regulation proteasome activity involves different mechanisms, such as substitution catalytic subunits, binding regulatory complexes gates conformational modifications triggered by protein itself. Mathematical models invaluable analysis; potentially allow us predict complex interactions mechanisms final outcomes degradation rate MHC class I epitope generation. pioneering attempts that been made mathematically model activity, preference variation their modification one reviewed here.