Treatment of acute myeloid leukemia patients aged more than 75 years: results of the E-AML-01 trial of the Japanese Elderly Leukemia and Lymphoma Study Group (JELLSG).
作者： Mayumi Mori , Masatsugu Ohta , Akira Miyata , Masaaki Higashihara , Kazuo Oshimi
DOI: 10.1080/10428190600733317
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摘要: The feasibility and effects of combination chemotherapy for very elderly patients with acute myeloid leukemia was examined in 65 (including previous myelodysplastic syndrome) aged 76 years or morewith a performance status 0 – 3. Induction performed 30 mg/m2 daunorubicin on days 1 3, 150 behenoyl cytosine arabinoside 7, 70 6-mercaptopurine 300 mg allopurinol taken orally 7 (BHAC-DM). complete remission (CR) rate 38.5%, whereas overall survival at 2 5 22.0% 4.7%, respectively. Two- 5-year CR 41.8% 11.2%, relapse the 25 64.0% disease-free 21.0% therapy-related mortality induction 13.8%. BHAC-DM is feasible effective selected patients.
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