An in vivo brain–bacteria interface: the developing brain as a key regulator of innate immunity

摘要: Infections have numerous effects on the brain. However, possible roles of brain in protecting against infection, and developmental origin role signaling immune response, are largely unknown. We exploited a unique Xenopus embryonic model to reveal control innate response pathogenic E. coli by developing Using survival assays, morphological analysis cells apoptosis, RNA-seq, we analyzed combinations removal, tail-regenerative response. Without brain, embryos injected with bacteria decreased significantly. The protective effect was mediated decrease infection-induced damage increase macrophage migration, as well suppression transcriptional consequences all which susceptibility pathogen. Functional pharmacological assays implicated dopamine bacteria–brain–immune crosstalk. Our data establish that reveals very early be central player immunity, identify origins brain–immune interactions, suggest several targets for therapies.