Adaptive changes in vitamin B12 absorption in celiac disease and after proximal small-bowel resection in man.

摘要: Resection of the proximal small bowel is known to cause mucosal hyperplasia and enhanced absorption in ileum experimental animals, but similar adaptive changes had not previously been studied man. Since intrinsic-factor-bound vitamin B12 (IF-B12) confined ileum, as an index ileal adaptation, we measured whole-body IF−58 Co 24 control subjects, 4 patients after small-bowel resection, 9 with adult celiac disease (where damage often limited intestine spares ileum). Control subjects absorbed 20.4% (±1sd 6.2%) administered 5-μg dose B12, while corresponding 7-day retention values resection (mean 42.3%; range 32–61%) 2 (44.1% 54%, respectively), were above normal range. The increased these suggests that functional adaptation also occurs results illustrate application a newly developed counting technique study