Occult primary tumors of the head and neck: lack of benefit from positron emission tomography imaging with 2-[F-18]fluoro-2-deoxy-D-glucose.

摘要: BACKGROUND Patients who present with squamous cell carcinoma metastatic to cervical lymph nodes and no clinically apparent primary site a therapeutic dilemma. Positron emission tomography imaging 2-[F-18]fluoro-2-deoxy-D-glucose (FDG-PET) has been shown be useful for the examination of known tumors. This study was undertaken determine whether FDG-PET improves detection occult tumors in patients head neck. METHODS Thirteen pathology proven node metastases from carcinomas were evaluated prospectively FDG-PET, addition standard clinical radiographic techniques, as part their pretreatment diagnostic evaluation. Direct panendoscopy biopsy performed on all an attempt detect tumor sites characterize them histologically. RESULTS A confirmed after 3 13 patients. The correctly identified only one these three suggested location where found 6 patients; 5 other patients, results negative found. No locations by computed tomography, magnetic resonance imaging, or direct panendoscopy. detected 1 patient (8%) provided false-positive (46%) patients. CONCLUSIONS FDG-PET did not significantly improve unknown neck. A high percentage false-positive. Cancer 1999;86:114–8. © 1999 American Society.