IMMUNOHISTOCHEMICAL ASSESSMENT OF HUMAN BONE MARROW MACROPHAGES IN HEMATOLOGIC DISORDERS

摘要: Changes in bone marrow macrophages may be associated with abnormal hematopoiesis various hematologic disorders. We immunohistochemically evaluated the density of trephine biopsies. In reactive erythroid hyperplasia (hemolytic anemia and megaloblastic anemia), slightly increased density, extending their cytoplasmic processes between hematopoietic cells. hypoplasia (pure red cell aplasia), they became rounded frequently had hemosiderin granules. There was no significant difference macrophage area hypoplasia. The myeloproliferative disorders (polycythemia vera, chronic myelogenous leukemia primary thrombocythemia). myelofibrosis, some extremely elongated along line fibroblastic contrast, conditions which myelopoietic activity is considerably impaired (aplastic anemia, acute multiple myeloma), significantly decreased density. These results suggest that morphologic change erythropoietic there a correlation activity.