Architecture shapes contractility in actomyosin networks.

摘要: Myosin-driven contraction of the actin cytoskeleton is at base cell and tissue morphogenesis. At molecular level, myosin motors drive by sliding filaments past one another using energy produced ATP hydrolysis. How this microscopic activity gives rise to cell-scale contractions has been an active research question first in muscle cells, over last few decades non-muscle cells. While many early investigations focused on motor activity, increasingly, nanoscale architecture network emerges as a key regulator contractility. Here we review theoretical vitro reconstitution studies that have uncovered some mechanisms which organization controls contractile tension generation. We then discuss recent findings indicating similar principles apply