Levamisole and hamster pouch carcinogenesis.

摘要: Seventy-five male and female Syrian hamsters (Cricetus auratus), 10 months of age, were studied for the effects systemically administered levamisole upon process chemical carcinogenesis buccal pouch mucosa. In twenty-five animals (Group II) left was painted three times weekly with a 0.5 per cent solution 9,10-dimethyl-1,2-benzanthracene (DMBA) in heavy mineral oil. After each topical application carcinogen to pouch, Group II received approximately 0.7 mg. hydrochloride orally by means pipette. another I) DMBA, but they not given levamisole. The III served as untreated controls. those which retarded. Fewer tumors developed, smaller size.