Further evidence for biological effects resulting from ionizing radiation doses in the diagnostic X-ray range.

摘要: In this study we assessed cell response to ionizing radiation doses in the diagnostic X-ray range, using metabolic performance as biological end point. HeLa cells were irradiated between 3.5 mGy (standard deviation (SD=2.5%) and 55.1 (SD=0.9%) with 110 kV X-rays, after 7 days capacity of cultures was measured spectrophotometrically resazurin. Cells receiving 7.5 or greater showed impaired proliferation. At effect prevented by nitric oxide synthase inhibitor N G-monomethyl-L-arginine but not ascorbic acid p38 MAPK SB203580. We conclude that proliferation is adversely affected within range some radiological examinations, through a mechanism involving oxide.