作者: Jessica M. A. Blair , Mark A. Webber , Alison J. Baylay , David O. Ogbolu , Laura J. V. Piddock
DOI: 10.1038/NRMICRO3380
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摘要: Antibiotic-resistant bacteria that are difficult or impossible to treat becoming increasingly common and causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New mechanisms constantly being described, new genes vectors transmission identified on regular basis. This article reviews recent advances in our understanding the either intrinsically resistant acquire antibiotics, including prevention access drug targets, changes structure protection antibiotic targets direct modification inactivation antibiotics.