The absolute bioavailability of oral vinorelbine in patients with solid tumors.

摘要: Due to advances in the methods used quantitate vinorelbine, this study was conducted characterize fully bioavailability of an oral dosage form vinorelbine. Twenty-seven eligible patients with solid tumors were enrolled onto and treated a randomized crossover design receive either 70 mg/m2 orally or 30 intravenously followed by alternative treatment one week later. Vinorelbine administered as soft-gelatin capsule. Pharmacokinetic sampling carried out for 7 days following each dose. Whole blood vinorelbine concentrations measured using sensitive LC/MS/MS method. The data from excluded if they vomited within 3 h after Results: Three subjects removed first dose due safety reasons. Of remaining 24 subjects, five experienced vomiting dosing. Total body clearance calculated intravenous 43.65 L/h (±10.9) terminal half-life estimated be 49 h. Using complete 19 mean absolute formulation 33% (±18%). In conclusion we have characterized pharmacokinetics both over administration determined 33%.