High-risk human papillomavirus reactivation in human immunodeficiency virus-infected women: risk factors for cervical viral shedding.

摘要: OBJECTIVE To evaluate the presence of and estimate risk factors for reactivation latent high-risk human papillomavirus (HPV) cervical infection in immunodeficiency virus (HIV)-infected HIV-uninfected women. METHODS Data from 898 women HIV Epidemiology Research Study (HERS) were used to HPV latency reactivation. Prior exposure types (16, 18, 31, 35, 45) was determined by serologic testing at enrollment, shedding detected polymerase chain reaction 6-month intervals. Human sexual history rates recurrence. Repeated measures survival analysis hazard ratios 95% confidence intervals Rates total (recurrence reactivation) during follow-up assessed status rate calculated. RESULTS Reactivation infections observed HIV-infected women, but few events identified Factors consistently associated with included CD4 count less than 200/mm age younger 35 years. Women infected had 1.8 8.2 times higher viral (reactivation plus recurrence) compared CONCLUSION a may be even absence activity, this is infection. LEVEL OF EVIDENCE II.