Development of T cell-mediated immunity after autologous stem cell transplantation: prolonged impairment of antigen-stimulated production of gamma-interferon.
作者： A M T van der Velden , A M E Claessen , H van Velzen-Blad , D H Biesma , G T Rijkers
关键词:
摘要: The conditioning regimens for autologous SCT (auto-SCT) lead to impairment of the immune system and concomitant increase in susceptibility infections. We studied recovery cellular immunity by vitro analysis T-cell proliferation cytokine production profiles during first 15 months after auto-SCT patients with multiple myeloma non-Hodgkin's lymphoma. PBMC were collected at 6, 9 transplantation stimulated a combination CD2 CD28 monoclonal antibodies, PHA or tetanus toxoid as recall antigen. A multiplex enzyme linked immunoassay was used determine levels Th1 cytokines IL-2, IFN-gamma tumour-necrosis factor-alpha (TNF-alpha), Th2 IL-4, IL-5 IL-13, regulatory IL-10 proinflammatory IL-1alpha, IL-1beta, IL-6 chemokine IL-8. progressively increased from 6 auto-SCT. Overall, Production IL-13 superior TNF-alpha. hypothesize that prolonged might contribute relatively high incidence viral infections
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