Pentosanpolysulfate (Elmiron) is a potent inhibitor of mast cell histamine secretion.
作者： George Chiang , Phani Patra , Richard Letourneau , Sheila Jeudy , William Boucher
DOI: 10.1007/978-1-4419-8889-8_44
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摘要: Interstitial cystitis (IC) is a sterile bladder condition that occurs primarily in women. It characterized by intense urinary frequency, urgency, burning, and suprapubic pain.56,61,74 The two most plausible, but not mutually exclusive, theories to explain the pathophysiology of IC are: (a) some defect protective glycosaminoglycan (GAG) layer mucosa,50 (b) an increased number activated mast cells.69 patients also suffer from allergies,40 irritable inflammatory bowel syndrome, migraines,70 all which are exacerbated stress.70,74
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C. Lowell Parsons, George Benson, Stacy J. Childs, Philip Hanno, Grannum R. Sant, George Webster, A Quantitatively Controlled Method to Study Prospectively Interstitial Cystitis and Demonstrate the Efficacy of Pentosanpolysulfate Journal of Urology. ,vol. 150, pp. 845- 848 ,(1993) , 10.1016/S0022-5347(17)35629-X
James A. Koziol, Douglas C. Clark, Ruben F. Gittes, Eng M. Tan, The Natural History of Interstitial Cystitis: A Survey of 374 Patients Journal of Urology. ,vol. 149, pp. 465- 469 ,(1993) , 10.1016/S0022-5347(17)36120-7
L. Parsons, D. Boychuk, S. Jones, R. Hurst, H. Callahan, Bladder Surface Glycosaminoglycans: An Epithelial Permeability Barrier Journal of Urology. ,vol. 143, pp. 139- 142 ,(1990) , 10.1016/S0022-5347(17)39897-X
M. Hohenfellner, L. Nunes, R.A. Schmidt, A. Lampel, J.W. Thüroff, E.A. Tanagho, Interstitial Cystitis: Increased Sympathetic Innervation and Related Neuropeptide Synthesis The Journal of Urology. ,vol. 147, pp. 587- 591 ,(1992) , 10.1016/S0022-5347(17)37314-7
Theoharides Tc, THE MAST CELL : A NEUROIMMUNOENDOCRINE MASTER PLAYER International Journal of Tissue Reactions-experimental and Clinical Aspects. ,vol. 18, pp. 1- 21 ,(1996)
Hidehiko Saito, Betty G. Uzman, Uptake of chondroitin sulfate by mammalian cells in culture. II. Kinetics of uptake and autoradiography. Experimental Cell Research. ,vol. 66, pp. 90- 96 ,(1971) , 10.1016/S0014-4827(71)80015-0
Erik Forsberg, Gunnar Pejler, Maria Ringvall, Carolina Lunderius, Bianca Tomasini-Johansson, Marion Kusche-Gullberg, Inger Eriksson, Johan Ledin, Lars Hellman, Lena Kjellén, Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme Nature. ,vol. 400, pp. 773- 776 ,(1999) , 10.1038/23488
GUNNAR D. BLOOM, Structural and Biochemical Characteristics of Mast Cells The Inflammatory Process. pp. 355- 388 ,(1965) , 10.1016/B978-1-4832-3297-3.50013-7
RM Nelson, O Cecconi, WG Roberts, A Aruffo, RJ Linhardt, MP Bevilacqua, Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation Blood. ,vol. 82, pp. 3253- 3258 ,(1993) , 10.1182/BLOOD.V82.11.3253.3253
R W Yurt, K F Austen, R W Leid, Native heparin from rat peritoneal mast cells. Journal of Biological Chemistry. ,vol. 252, pp. 518- 521 ,(1977) , 10.1016/S0021-9258(17)32747-3