Therapeutic Potential of Human Chorionic Gonadotropin Against Painful Bladder Syndrome/Interstitial Cystitis.

作者: C.V. Rao

DOI: 10.1177/1933719116639139

关键词:

摘要: Painful bladder syndrome/interstitial cystitis is a debilitating chronic disease that primarily affects women. The due to damage of urothelial cell lining. As result, potassium particles and other toxic substances in urine can leak into mucosa, causing the symptoms lower abdominal/pelvic discomfort, pain, increased urination frequency, urgency, nocturia, so on, all which substantially reduce quality daily life. There are multiple symptom reliving therapies. Among them, only pentosan polysulfate sodium, sold under brand name Elmiron, has been approved for oral use by US Food Drug Administration. It provides relief after several months use. Based on scientific leads presented this article, we propose human chorionic gonadotropin therapeutic potential worth investigating treatment disease.

参考文章(104)
George Chiang, Phani Patra, Richard Letourneau, Sheila Jeudy, William Boucher, Marlon Green, Grannum R. Sant, Theoharis C. Theoharides, Pentosanpolysulfate (Elmiron) is a potent inhibitor of mast cell histamine secretion. Advances in Experimental Medicine and Biology. ,vol. 539, pp. 713- 729 ,(2003) , 10.1007/978-1-4419-8889-8_44
C. Lowell Parsons, George Benson, Stacy J. Childs, Philip Hanno, Grannum R. Sant, George Webster, A Quantitatively Controlled Method to Study Prospectively Interstitial Cystitis and Demonstrate the Efficacy of Pentosanpolysulfate Journal of Urology. ,vol. 150, pp. 845- 848 ,(1993) , 10.1016/S0022-5347(17)35629-X
E. C. AMOROSO, Endocrinology of pregnancy. British Medical Bulletin. ,vol. 11, pp. 117- 125 ,(1955) , 10.1093/OXFORDJOURNALS.BMB.A069463
S. Gutue, C. Persu, P. Geavlete, Irina Blaj, V. Jinga, V. Cauni, From interstitial cystitis to chronic pelvic pain. Journal of medicine and life. ,vol. 3, pp. 167- 174 ,(2010)
P Policastro, C E Ovitt, M Hoshina, H Fukuoka, M R Boothby, I Boime, The beta subunit of human chorionic gonadotropin is encoded by multiple genes. Journal of Biological Chemistry. ,vol. 258, pp. 11492- 11499 ,(1983) , 10.1016/S0021-9258(17)44254-2
J S Davis, L A West, R V Farese, Effects of luteinizing hormone on phosphoinositide metabolism in rat granulosa cells. Journal of Biological Chemistry. ,vol. 259, pp. 15028- 15034 ,(1984) , 10.1016/S0021-9258(17)42509-9
A.G. Daifotis, E.C. Weir, B.E. Dreyer, A.E. Broadus, Stretch-induced parathyroid hormone-related peptide gene expression in the rat uterus. Journal of Biological Chemistry. ,vol. 267, pp. 23455- 23458 ,(1992) , 10.1016/S0021-9258(18)35857-5
C.V. Rao, Paradigm shift on the targets of hCG actions Human Chorionic Gonadotropin (HGC). pp. 141- 147 ,(2015) , 10.1016/B978-0-12-800749-5.00015-8