Inhibitors of Myosin Light Chain Kinase Block Synaptic Vesicle Pool Mobilization during Action Potential Firing
作者： Timothy A. Ryan
DOI: 10.1523/JNEUROSCI.19-04-01317.1999
关键词:
摘要: During repetitive action potential firing the maintenance of synaptic transmission relies on a continued supply vesicles for fusion with presynaptic plasma membrane. The mechanism transport by which are delivered to site from reserve pool is unknown, as biochemical pathways linking intracellular Ca2+ elevation vesicle mobilization. Here, using fluorescent tracer FM1-43 in hippocampal terminals, I show that inhibitors myosin light chain kinase can block mobilization and not immediately releasable pool.
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