High expression of the autophagy gene Beclin-1 is associated with favorable prognosis for salivary gland adenoid cystic carcinoma

摘要: J Oral Pathol Med (2012) 41: 621–629 Background:  Although autophagy is universally involved in tumorigenesis and tumor progression, the roles of autophagy-regulating genes salivary gland adenoid cystic carcinoma (ACC) remain unknown. In this study, we investigated expression Beclin-1, death-associated protein kinase-1, ultraviolet radiation resistance–associated gene, phosphatase tensin homolog ACC samples. Methods:  Immunohistochemistry real-time polymerase chain reaction were used to analyze these 89 samples normal tissue samples. The relationship their with clinicopathological features was analyzed. Results:  data showed significantly lower than Furthermore, Beclin-1 correlated histological pattern (P < 0.05), high gene associated distant metastasis (P < 0.05). Most importantly, univariate multivariate survival analyses suggested that mRNA cancer cells independent prognostic indicators for ACC. Conclusion:  Our results suggest may participate pathogenesis ACC. Further research will be required gain a better understanding