Fractures in Healthy Females Followed from Childhood to Early Adulthood Are Associated with Later Menarcheal Age and with Impaired Bone Microstructure at Peak Bone Mass

摘要: Background: Whether fractures observed in healthy children are associated with microstructural alterations and strength deficit that persists by the end of growth period is not established. Considering importance pubertal timing bone development, we also quantified fracture risk related to later menarcheal age (MENA). Participants Methods: We followed 124 girls from mean ± sd 7.9 0.5 20.4 0.6 yr. Fractures, MENA, radius areal mineral density (aBMD) were recorded at regular intervals. At a yr, variables distal determined high-resolution peripheral computerized tomography micro-finite element analysis. Results: Sixty-one occurred 42 subjects. subjects had lower aBMD radial diaphysis (P = 0.005) metaphysis 0.008), trabecular volumetric (vBMD) 0.010) thickness 0.014), reduction stiffness (P...