Impact of Andrographis paniculata crude extract on mouse hepatic cytochrome P450 enzymes.
作者： Kanokwan Jarukamjorn , Kannika Don-in , Cattaleya Makejaruskul , Thewarach Laha , Supawadee Daodee
DOI: 10.1016/J.JEP.2005.11.024
关键词:
摘要: Modulatory influence of Andrographis paniculata crude extract on cytochrome P450 (CYP) enzymes was performed by administration the to ICR male mice. Total hepatic content not significantly modified either aqueous or alcoholic extracts paniculata. Assessment microsomal activities alkoxyresorufin O-dealkylations noted that both and increased ethoxyresorufin O-dealkylase pentoxyresorufin activities, while those methoxyresorufin were elevated. These results suggested might effectuate which CYP1A1 CYP2B are responsive isoforms.
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