Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
作者： Srinivas Nanduri , Vijay Kumar Nyavanandi , Siva Sanjeeva Rao Thunuguntla , Sridevi Kasu , Mahesh Kumar Pallerla
DOI: 10.1016/J.BMCL.2004.06.090
关键词:
摘要: Andrographolide 1, the cytotoxic agent of plant Andrographis paniculata was subjected to semi-synthetic studies leading preparation a number potent and novel analogues. Of analogues synthesized, while 8,17-epoxy andrographolide 6 retained activity ester derivatives exhibited considerable improvement in activity. Lower observed when epoxy moiety triacetate 9, derived from modified. Synthesis structure-activity relationships are discussed.
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