THE ROLE OF ETHYL ACETATE FRACTION OF ANDROGRAPHIS PANICULATA AND DOXORUBICIN COMBINATION TOWARD THE INCREASE OF APOPTOSIS AND DECREASE OF VEGF PROTEIN EXPRESSION OF MICE FIBROSARCOMA CELLS
作者： Triana Balqianur , Sukardiman , Suharjono
DOI:
关键词:
摘要: Objective : The objective of this study is to prove the role an ethyl acetate fraction Andrographis paniculata and doxorubicin combination toward increase apoptosis decrease VEGF protein expression mice fibrosarcoma cells. Methods were injected subcutaneously on scapular with benzo(a)pyrene once every 2 days for 10 induce after 3 months they randomly divided into four groups, consisting of: negative control, A. group, group. By immunohistochemistry preparation, cells scored expression. Results Ethyl significantly (p<0.05) apoptosis. also Conclusion It can be concluded that Decrease led inhibition tumor growth, neovascularization, in proliferation formation necrosis.
innovareacademics.in
unair.ac.id参考文章(20)
Tan Guak Kim, Kim Kah Hwi, Cheah Swee Hung, Morphological and Biochemical Changes of Andrographolide-induced Cell Death in Human Prostatic Adenocarcinoma PC-3 Cells in Vivo. ,vol. 19, pp. 551- 557 ,(2005)
Julie M. Cherrington, Laurie M. Strawn, Laura K. Shawver, New paradigms for the treatment of cancer: The role of anti-angiogenesis agents Advances in Cancer Research. ,vol. 79, pp. 1- 38 ,(2000) , 10.1016/S0065-230X(00)79001-4
Marcus Lehnhardt, Ludger Klein-Hitpass, Cornelius Kuhnen, Heinz Herbert Homann, Adrien Daigeler, Hans Ulrich Steinau, Sonja Roehrs, Laura Schnoor, Lars Steinstraesser, Oliver Mueller, None, Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. ,vol. 5, pp. 74- 89 ,(2005) , 10.1186/1471-2407-5-74
Bronislaw Pytowski, William O’Connor, Daniel J. Hicklin, Andrea Hooper, Yiwen Li, Karen King, Angel Santiago, Peter Bohlen, James Huber, Jay Overholser, Larry Witte, Marie Prewett, Antivascular Endothelial Growth Factor Receptor (Fetal Liver Kinase 1) Monoclonal Antibody Inhibits Tumor Angiogenesis and Growth of Several Mouse and Human Tumors Cancer Research. ,vol. 59, pp. 5209- 5218 ,(1999)
M E Peter, P H Krammer, The CD95(APO-1/Fas) DISC and beyond Cell Death & Differentiation. ,vol. 10, pp. 26- 35 ,(2003) , 10.1038/SJ.CDD.4401186
Hiroyuki Takahashi, Masabumi Shibuya, The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clinical Science. ,vol. 109, pp. 227- 241 ,(2005) , 10.1042/CS20040370
Napoleone Ferrara, Terri Davis-Smyth, THE BIOLOGY OF VASCULAR ENDOTHELIAL GROWTH FACTOR Endocrine Reviews. ,vol. 18, pp. 4- 25 ,(1997) , 10.1210/EDRV.18.1.0287
Srinivas Nanduri, Vijay Kumar Nyavanandi, Siva Sanjeeva Rao Thunuguntla, Sridevi Kasu, Mahesh Kumar Pallerla, P. Sai Ram, Sriram Rajagopal, R. Ajaya Kumar, Rajagopalan Ramanujam, J. Moses Babu, Krishnamurthi Vyas, A. Sivalakshmi Devi, G. Om Reddy, Venkateswarlu Akella, Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. ,vol. 14, pp. 4711- 4717 ,(2004) , 10.1016/J.BMCL.2004.06.090
Jing Zhou, Siyuan Zhang, Ong Choon-Nam, Han-Ming Shen, None, Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochemical Pharmacology. ,vol. 72, pp. 132- 144 ,(2006) , 10.1016/J.BCP.2006.04.019
Ying HAN, Li Min BU, Xin JI, Chun Yan LIU, Zhi Hong WANG, Modulation of multidrug resistance by andrographolid in a HCT-8/5-FU multidrug-resistant colorectal cancer cell line Chinese Journal of Digestive Diseases. ,vol. 6, pp. 82- 86 ,(2005) , 10.1111/J.1443-9573.2005.00197.X