Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat.

摘要: Herbal extracts targeting at the brain remain a continuous challenge to pharmacology. Usually, number of different animal tests have be performed in order find potential clinical use. Due manifold possibly active ingredients biochemical approaches are difficult. A more holistic approach using neurophysiological technique has been developed earlier characterise synthetic drugs. Stereotactic implantation four semi-microelectrodes into frontal cortex, hippocampus, striatum and reticular formation rats allowed wireless monitoring field potentials (EEG) before after drug intake. After frequency analysis (Fast Fourier Transformation) electric power was calculated for 6 ranges (delta, theta, alpha1, alpha2, beta1 beta2). Data from 14 drugs - tested representative indications were taken construction discriminant functions showing projection patterns six-dimensional graph. Quantitative EEG pattern depth succeeded discrimination effects according their known indication (Dimpfel Schober, 2003). Extracts Valerian root, Ginkgo leaves, Paullinia seed, Hop strobile, Rhodiola rosea root Sideritis scardica herb now under identical conditions. Classification these based on matrix revealed that hop induced reminiscent physiological sleep. appeared close neighbourhood stimulatory like caffeine or an analgesic profile (tramadol). similar comparable psychostimulant (methylphenidate) as well antidepressive (paroxetine).