Plasmacytoid Dendritic Cells: A New Cutaneous Dendritic Cell Subset with Distinct Role in Inflammatory Skin Diseases

摘要: Epidermal dendritic cells found in inflamed skin include Langerhans and the recently identified population of inflammatory epidermal cells. Another subset humans is plasmacytoid cell peripheral blood, which characterized by production large amounts type I interferon (interferon-α interferon-β) upon viral infection. We hypothesized that might be involved anti-viral defense mechanisms skin. Here we investigated cells, single suspensions normal looking from healthy volunteers lesional patients with different diseases. were samples. In skin, low or absent. Lesional samples psoriasis vulgaris contact dermatitis contained relatively high numbers both contrast, many but only very few could detected atopic lesions. Lupus erythematosus was These results demonstrate addition to resident are selectively recruited lesions depending on disease. The lack may predispose infections such as eczema herpeticum, a secondary infection herpes simplex virus. composition subsets help clarify etiology diseases forms basis for therapeutic intervention selective microbial molecules immunostimulatory CpG oligonucleotides.