Rabbit gut permeability in response to histamine chloramines and chemotactic peptide.
作者： Mark J.S. Miller , Xiao-Jing Zhang , Brian Barkemeyer , Matthew B. Grisham , Halina Sadowska-Krowicka
DOI: 10.1016/0016-5085(92)91175-4
关键词:
摘要: Granulocyte-derived chlorinated amines and bacterial formyl peptides are thought to enhance epithelial permeability. In the current study, gut permeability [51Cr]ethylenediaminetetraacetic acid (EDTA) was monitored in response luminal formyl-methionyl-leucyl-phenylalanine (fMLP) histamine monochloramine dichloramine. Responses were determined rabbits during states of basal elevated Luminal fMLP had minimal effects control injured states. Histamine or dichloramine enhanced under conditions; this effect exaggerated by a pre-existing injury. Both retained full agonist properties, combination antioxidant antihistamine therapy required block increase Whereas chloramines caused dose-dependent cytotoxicity rat-cultured enterocytes, marked histological changes mucosa not evident, nor mucosal glutathione levels depleted. As retain histaminergic oxidizing potential their precursors, they represent unique form inflammatory mediator, although highly reactive nature precludes vivo confirmation formation.
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sci-hub.se 参考文章(41)
M B Grisham, M M Jefferson, E L Thomas, Role of monochloramine in the oxidation of erythrocyte hemoglobin by stimulated neutrophils. Journal of Biological Chemistry. ,vol. 259, pp. 6757- 6765 ,(1984) , 10.1016/S0021-9258(17)39793-4
K.D. Katz, D. Hollander, C.M. Vadheim, C. McElree, T. Delahunty, V.D. Dadufalza, P. Krugliak, J.I. Rotter, Intestinal permeability in patients with Crohn's disease and their healthy relatives Gastroenterology. ,vol. 97, pp. 927- 931 ,(1989) , 10.1016/0016-5085(89)91499-6
M B Grisham, M M Jefferson, D F Melton, E L Thomas, Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines. Journal of Biological Chemistry. ,vol. 259, pp. 10404- 10413 ,(1984) , 10.1016/S0021-9258(18)90979-8
D.Neil Granger, Barbara J. Zimmerman, Eiichi Sekizuka, Matthew B. Grisham, Intestinal Microvascular Exchange in the Rat During Luminal Perfusion With Formyl-Methionyl-Leucyl-Phenylalanine Gastroenterology. ,vol. 94, pp. 673- 681 ,(1988) , 10.1016/0016-5085(88)90238-7
Mark J.S. Miller, Xiao-Jing Zhang, Xiang Gu, David A. Clark, Acute intestinal injury induced by acetic acid and casein: Prevention by intraluminal misoprostol Gastroenterology. ,vol. 101, pp. 22- 30 ,(1991) , 10.1016/0016-5085(91)90455-T
Ingvar Bjarnason, Colm O'Morain, A.Jonathan Levi, Timothy J. Peters, Absorption of 151chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease Gastroenterology. ,vol. 85, pp. 318- 322 ,(1983) , 10.1016/0016-5085(83)90317-7
Charity C. Fox, Audrey J. Lazenby, Wendy C. Moore, John H. Yardley, Theodore M. Bayless, Lawrence M. Lichtenstein, Enhancement of human intestinal mast cell mediator release in active ulcerative colitis Gastroenterology. ,vol. 99, pp. 119- 124 ,(1990) , 10.1016/0016-5085(90)91238-2
Christoph von Ritter, Eiichi Sekizuka, Matthew B. Grisham, D. Neil Granger, The Chemotactic Peptide N-Formyl Methionyl-Loucyl-Phenylalanine Increases Mucosal Permeability in the Distal Ileum of the Rat Gastroenterology. ,vol. 95, pp. 651- 656 ,(1988) , 10.1016/S0016-5085(88)80011-8
G W Gullikson, T S Gaginella, C Moummi, M B Grisham, Differential effects of reactive oxygen metabolites on neurally stimulated and nonstimulated guinea pig ileum. Journal of Pharmacology and Experimental Therapeutics. ,vol. 256, pp. 266- 271 ,(1991)
G Olaison, P Leandersson, R Sjodahl, C Tagesson, Intestinal permeability to polyethyleneglycol 600 in Crohn's disease. Peroperative determination in a defined segment of the small intestine. Gut. ,vol. 29, pp. 196- 199 ,(1988) , 10.1136/GUT.29.2.196