Hemagglutination inhibition antibody titers as a correlate of protection against seasonal A/H3N2 influenza disease

摘要: Background. To investigate the relationship between hemagglutinin-inhibition (HI) antibody levels to risk of influenza disease, we conducted a correlate protection analysis using pooled data from previously published randomized trials. Methods. Data on occurrence laboratory-confirmed and HI pre- postvaccination were analyzed 4 datasets: 3 datasets included subjects aged <65 years who received inactivated trivalent vaccine (TIV) or placebo, 1 dataset ≥65 AS03-adjuvanted TIV (AS03TIV) TIV. A logistic model was used evaluate titer A/H3N2 antibodies disease. We then built receiver-operating characteristic curve identify potential cutoff no protection. Results. The baseline odds ratio disease higher for than in seasons strong epidemic intensity moderate low intensity. Including age as covariates, 4-fold increase associated with 2-fold decrease Conclusions. modeling exercise confirmed responses, but it did not allow an evaluation predictive power response.